Oxidative Stress :: Health, Diseases

Oxidative try on plays a critical role in the pathogenesis of various diseases including cancer, atherosclerosis, ischemic injury, irritation and neurodegenerative diseases such as Parkinsons and Alzheimers. As aerophilous stress expertness be an important part of many human diseases, the use of antioxidants in pharmaceuticals and nutraceuticals is intensively studied. Natural antioxidants have been the focus of considerable interest in recent times 22. To date antioxidant activity of E. cava has been extensively studied and documented. E. cava extracts and the discriminate compounds exhibited strong antioxidant activity and this proven antioxidant properties of the brownness seaweed as a blue-chip natural antioxidant source have been utilized into several industrial applications 23. superstar of the previous studies 10 has shown antioxidant activities of phlorotannins purified from E. cava on free understructure scavenging using electron device resonance (ESR). The potentia l antioxidant activities of three phlorotannins namely phloroglucinol, eckol and dieckol purified from E. cava were evaluated and all the compounds showed potential radical scavenging activities and potential inhibitory effects on H2O2-mediated DNA detriment as well. In addition, promising antioxidant properties of E. cava were inform with novel phlorotannin derivatives 7. They have isolated and characterized heptad phlorotannins from E. cava and according to the results all the phlorotannins exhibited potent antioxidant properties. Kang et al. 24 have investigated the cytoprotective effect of eckol, which was isolated from E. cava, against aerophilous stress induced booth damage in V79-4 cells. Further, they suggested that eckol protects V79-4 cells against oxidative damage by enhancing the cellular antioxidant activity and modulating cellular signal pathway.Antioxidative effect of E. cava dried-out by far infrared radiation drying was reported by lee(prenominal) et al. 25. Methanolic extract from E. cava dried by far infrared radiation drying enhance cell viability and H2O2 scavenging activity in Vero cells. It was also found that dieckol a phlorotannin was the major(ip) antioxidant compound in this work. Interestingly, a study in antioxidant activity of brown algal phlorotannins demonstrated that phlorotannins of E. cava had significant radical scavenging activities against the superoxide anion and DPPH, and were more useful compared to ascorbic acid and -tocopherol 26. Triphlorethol-A phlorotannin found in E. cava, protects V79-4 cells against oxidative stress induced cell death through up regulation of heme oxygenase-1 (HO-1) 27. Further, they suggested triphlorethol-A augments cellular antioxidant defensive structure capacity through induction of HO-1 via ERK-Nrf2-ARE signaling pathway, thereby protecting cells from oxidative stress. In another study cytoprotective effect of triphlorethol-A against -ray radiation-induced oxidative stress was rep orted 28.